A study on the distribution of 3-methylcholanthrene-inducible cytochrome P-450 within the hepatic lobulus of rats.

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概要

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• The effect of 3-mehylcholanthrene (MC) on the distribution of MC-inducible cytochrome P-450 (cytochrome P-450MC) within the hepatic lobulus of rats was investigated by the indirect fluorescent antibody staining technique. Rabbit antiserum produced against cytochrome P-450MC was used in this experiment. The effect of chronic ethanol feeding on the distribution of cytochrome P-450MC in the hepatic lobulus was also studied. In the control rats, the specific fluorescence was barely observed, being slightly more intense in the centrilobular and the midzonal hepatocytes than in the periportal hepatocytes. The effect of MC on the distribution of cytochrome P-450MC was investigated at 6, 12, 24 and 48 hours after peritoneal injection of 20mg MC/kg body weight. The intensity of the specific fluorescence increased with time and was almost equal among the three zones of the hepatic lobulus in all the stages investigated. No difference was observed between chronic ethanol feeding rats and control rats in the intensity and distribution of the specific fluorescence.

• 社団法人 日本肝臓学会の論文

著者

• 河田 純男

  大阪大学医学部第二内科

• 山野 俊雄

  大阪大学医学部

• 岡本 光弘

  大阪大学医学部

• 田村 信司

  大阪大学医学部第二内科

• 垂井 清一郎

  大阪大学医学部小児科学教室

• 西川 正博

  大阪大学医学部第二内科

• 南 雄三

  大阪大学医学部第2内科

• 三好 志雄

  大阪大学医学部第2内科

• 稲田 正己

  大阪大学医学部第2内科

• 斉藤 隆三

  大阪大学医学部第2内科

• 岡本 光弘

  大阪大学医学部生化学

• 乾 由明

  大阪大学医学部第2内科

• 野田 修造

  大阪大学医学部第2内科

• 今井 康陽

  大阪大学医学部第2内科

• 垂井 清一郎

  大阪大学医学部中央臨床検査部

• 田村 信司

  大阪大学医学部第2内科

• 西川 正博

  大阪大学医学部第2内科

• 河田 純男

  大阪大学医学部第2内科

• 山野 俊雄

  大阪大学医学部生化学

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