Effect of Parathyroid Function on the Uric Acid Metabolism in a Case of Primary Gout Associated with Parathyroid Adenoma and Renal Cell Carcinoma

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In order to elucidate the influence of parathyroid function on uric acid metabolism, a case of primary gout with parathyroid adenoma was studied before and after adenectomy. The serum calcium level was 5.13±0.15(mean±SE)rnEq/l and serurn 1,25(OH)2D was 71.5pg/ml(normal: 24.9-65.5) before adenectomy. After the operation the serum calcium and 1,25(OH)2D levels decreased significantly to 4.35±0.12mEq/l and 18.0 pg/ml, respectively. Although the serum urate remained almost unchanged before and after the operation, the ratio of urate to creatinine clearance increased considerably from 4.93±0.75% to 6.80±0.74%. These data suggest that parathyroid function such as regulation of serum calcium and 1,25 (OH)2D might influence uric acid metabolism.
Japanese Society of Gout and Nucleic Acid Metabolismの論文