Pathogenesis of Hyperuricemia in Glycogenosis Type VII:a contribution of an exaggerated degradation of purine nucleotides in exercising muscle

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概要

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• To elucidate the pathogenesis of hyperuricemia in glycogenosis type VII, we investigated a possible role of altered purine metabolism in exercising muscle in this disorder. Semi-ischemic forearm exercise test wa s performed in unrelated two patients with glycogenosis type VII. Despite of no increases in venous lactate levels, marked elevations of venous ammonia were observed (5.6- and 10.1-fold of control values, respectively), indicating an acceleration of AMP deamination in muscle. This observation suggests that there is an exaggerated degradation of purine nucleotides in exercising muscle and this may contribute to the development of hyperuricemia in glycogenosis type VII.

• Japanese Society of Gout and Nucleic Acid Metabolismの論文

著者

• 河野 典夫

  大阪大学医学部保健学科

• 野中 共平

  大阪大学医学部第二内科

• 嶺尾 郁夫

  大阪大学医学部第二内科

• 清水 孝郎

  大阪大学医学部第二内科

• 鷲見 誠一

  大阪大学医学部第二内科

• 垂井 清一郎

  大阪大学医学部中央臨床検査部

• 松沢 佑治

  大阪大学医学部第二内科

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