Study on purine metabolismn Purine nucleoside phosphorylase

概要

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Purine nucleotide biosynthesis in human leukocytes completely depends on the salvage pathway since no capacity of purine biosynthesis de novo has been recognized in them. Since the report by Giblett et al. of the primary immunodeficiency associated with purine nucleoside phosphorylase ( PNP ) deficiency, the physiological importance of PNP was further confirmed. When PNP activity is low in leukocytes, the rate of purine nucleotide biosynthesis seems to decrease, In addition, it was recognized that the growth of human T-lymphocytes in vitro was inhibited by the presence of guanosine which is one of the substrates of PNP and that the granulocyte colony formation from mouse bone marrow cells in vitro was also inhibited. The inhibition seems to occur as a result of the decrease in pyrimidine biosynthesis de novo. The PNP activity of leukemic cells was examined, which was low in AGL, AMoL and CGL. The reason of these low values of PNP is speculated.
Japanese Society of Gout and Nucleic Acid Metabolismの論文