Association between the Acetylation Genetic Polymorphism and Drug-Induced Lupus Erythematosus. Isoniazid Drug-Induced Lupus Erythematosus.:Isoniazid Drug-Induced Lupus Erythematosus

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The association between acetylation genetic polymorphism and drug-induced lupus erythematosus with use of isoniazid as the pharmacogenetic probe was studied. Acetylator phenotype of isoniazid (INH) was studied in 129 unrelated pulmonary tuberculosis patients. Urine samples were collected over 8hr. INH and acetylisoniazid (AcINH) in urine were assayed by HPLC. From a frequency histogram and probit plot, the results of the log10 of the metabolic ratios (molar acetylation ratio) indicated the existence of two modes. The frequency of slow acetylators was 10%. And the antinuclear antibody was determined by indirect immunofluorescence. Thirty-five of 129 patients (27%) had development of antinuclear antibodies (homogenous). Two cases out of the 35 (8.6%) were slow acetylators. The relationship between phenotype distribution and possible pathoetiologic factor is discussed.