臨床検査における強酸中の呈色反応機構

概要

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Many color reaction of organic componnds in Brønsted or Lewis acid medium which have been used for the detection and the determination of biological materials or for organic analyses are well known. In this review, some of the reaction mechanisms of these coloration, the coloration of aromatic aldehyde with electrophilic reagent in sulfuric acid such as the de Fazi reaction and the Molisch reaction, the coloration of cholesterol in strong acid such as the Liebermann-Burchard reaction, the Zak reaction, the Hirschsohn reaction, the Mueller reaction and the reaction of cholesterol with benzoyl peroxide, the coloration of sexual hormone in acid such as the Kober reaction, the Mueller reaction of estrone and the reaction of teststerone, the Carr-Price reaction, and the Marquis reaction, were reviewed. Among them, the most of coloration using sulfuric acid or other protic acid as the reaction medium were ascribed to carbocation formation, while the color in the Molisch reaction and the Marquis reaction might arise from cation-radical, and the colorations in antimonyl trichloride reagent were ascribed to cation-radical formation.
社団法人有機合成化学協会の論文