胆・膵腫瘍診断における腫瘍マーカーの意義

概要

論文の詳細を見る
Although endoscopic retrograde pancreatography (ERCP) is the mainstay in the diagnosis of pancreatic cancer, it can be difficult to distinguish between pancreatic cancer and chronic pancreatitis. During three year-period we encountered 64 patients with suspected pancreatic cancer on the basis of ERCP. Final diagnosis of these 64 patients is; pancreatic cancer in 53 patients and chronic pancreatits in the other 11. Abnormally elevated serum levels of CA19-9 and carcinoembryonic antigen (CEA) were observed in 95.0% and 52.3% of patients with pancreatic cancer, and 27.3% and 27.3% of patients with chronic pancreatitis, respectively. Measurement of serum CA19-9 may help to differentiate between the two entities, but is not specific for pancreatic cancer. In patients with cholangiocarcinoma serum CA19-9 and CEA are positive only in 37% and 80%, respectively. Development of sophisticated imaging modalities and techniques to sample biopsy specimen may increase the diagnostic yield of pancreatic and biliary neoplasms.
Kinki Brain Tumor Pathology Conferenceの論文