骨肉腫様変化を呈した肝細胞癌の1例

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We report a case of hepatocellular carcinoma associated with sarcomatous change and ossification in a 77-year-old male. The hepatic mass with calcification was detected in the right posterior segment of the liver using abdominal ultrasonography in June, 1990. Pathological findings for the tumor after fine needle biopsy of the hepatic mass was performed consisted of sarcoma with osteoid cells. Pathological findings for a fist sized tumor with tenderness detected at the right iliac bone consisted of poorly differentiated hepatocellular carcinoma. Serum alpha-fetoprotein (AFP) was 45, 449 ng/ml, carcinoembryonic antigen 32.7ng/m/, and protein induced by vitamin K absence or antagonist-II 1.22 Au/m/, AFP subfractions separated by affinity electrophoresis with Lens culinaris agglutinin A (LCA-A) revealed pattern consistent with hepatocellular carcinoma. On the basis of clinical course, value of tumor marker, and histological findings for the tumors, this hepatic mass was diagnosed as primary hepatoma with sarcomatous change, ossification, and osseous metastasis.
社団法人日本肝臓学会の論文