鼻アレルギ-に対するHistaglobinの臨床効果--二重盲検試験による検討

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A double blind study using Histaglobin was carried out on 120 patients with nasal allergy, twenty-six dropped out of the study.The test resulted in 5 "remarkably effective", 18 "effective", 13 "rather effective", and 11 "ineffective" in the Histaglobin group, and 1 "remarkably effective", 7 "effective", 13 "rather effective", and 26 "ineffective" in the placebo group. The "effective" rate including "rather effective" is 76.6% in Histaglobin group and 44.7% in placebo group, and the "effective" rate excluding "rather effective" is 48.9% in Histaglobin group and 17% in the placebo group. In either case, the "effective" rate in the Histaglobin group was superior to rates in the placebo group, and there was a statistically significant difference.A significant difference in the improvement of subjective symptoms was observed with regard to sneezing, nasal discharge, the degree of general subjective symptoms. No significant difference was observed in the degree of improvement of nasal obstruction.For the improvement of the observations of nares, a significant difference was observed in the degree of improvement of the swelling of inferior nasal concha, the color tone, and the general observation of nares, but no significant difference was observed in the improvement of discharge.As to the intracutaneous reaction, challenging reaction, and the changes of the count of eosinocytes in the nasal discharge, no significant difference was observed in the two groups.In Histamine reaction, however, a significant difference was observed in Histaglobin group.Side effects were not observed in any case.
耳鼻咽喉科臨床学会の論文

鼻アレルギ-に対するHistaglobinの臨床効果--二重盲検試験による検討

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