鼓室の急性炎症における内耳液の免疫学的研究

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By means of antigen antibsdy crossed electrophoresis (Laurell), protein components in endolymph and perilymph of guinea pig inner ear were analized under acute middle ear inflammation. 1) Group of silver protein otitis media: Silver protein was injected into the tympanic cavity. In 30 minutes following injection, all of the precipitation arcs in both fluids were obserbed very distinctly. Especially the peak of *-Globulin arc shifted toward the high position and the area under precipitation arc increased. A/*-GI was 0. 64 in endolymph and 0. 76 in perilymph. In 24 hours following injection, A/*-G was 1.04 in endolymph and 0. 74 in perilymph. In 10 days following injection, immunoelectrophoreograms of both fluids showed same patterns as of normal group. 2) Group of allergic otitis media: An egg white albumin was injected into the tympanic cavity of sensitized animal. In 30 minutes following injection, A/*-G was 0. 60 in endolymph. Several precipitation arcs were not observed in normal subjects and were noted in *-, *-, and *-Globulin fractions of endolymph and perilymph. In 24 hours following injection, this tendency was found in all of perilymph, but was not seen in endolymph. A/*-G was 1.28 in endolymph and 0. 94 in perilymph. In 10 days following injection, immunoelectrophoreograms of both fluids showed the same patterns as of normal group. From these results obtained, in all subjects following injection of egg white albumin as well as silver protein, the immunoelectrophoreogram was changed immediately and remarkably. Several protein components of serum in acute middle ear inflammation infiltrated into the inner ear fluids. Especially -Globulin increased cosiderably in perilymph in cases of allergic otitis media, but these changes showed a tendecy to recover within 10 days.
社団法人日本耳鼻咽喉科学会の論文

著者

鈴木康之
名古屋大学大学院医学系研究科泌尿器科学

鼓室の急性炎症における内耳液の免疫学的研究

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