Study of tissue concentration of clindamycin-2-phosphate and its clinical usefulness.

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The concentration of clindamycin-2-phosphate (CLDM-P) in blood, maxillary sinus mucosa and middle-ear mucosa following intravenous drip infusion for 30 minutes were determined in surgical patients in the otorhinolaryngology department. The clinical usefulness of CLDM-P was assessed in five cases of peritonsillar abscess. CLDM-P showed a peak blood concentration of 9.654±3.770ug/ml at the end of infusion, with a half-life of 4.43 hours.Concentrations of CLDM-P in maxillary sinus mucosa and middle-ear mucosa averaged 9.312±2.476ug/g and 3.63±1.756ug/g respectively.Anaerobes were isolated in all five cases of peritonsillar abscess. Aerobes were also detected in three cases. In treating these five cases, CLDM-P proved excellent in four and good in one. No adverse reaction was noted in any of the five.The blood and tissue concentrations, minimal inhibitory concentrations and clinical effectiveness, indicate that CLDM-P is a very useful antibiotic for otorhinolaryngological infections.
耳鼻咽喉科臨床学会の論文