Effect of H2-blockers, cimetidine and famotidine, on nasal sensitivity.

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It has been reported that histamine could increase the cyclic-AMP level via the H2-receptors present on the basophilic cells and that H2-receptors might be responsible for the negative feedback control of mediator release. Therefore, treatment with H2-blockers might be contraindicated in allergic patients. It has already been reported that Cimetidine increases bronchial sensitivity.In this study, nasal reactions to Cimetidine and Famotidine treatment were evaluated in 10 healthy adults by the histamine nasal provocation test (HPT) in a double-blind, cross-over trial. The HPT was conducted before treatment and 3 and 7 days after the start of treatment.The nasal reaction to histamine was not significantly changed by the administration of Famotidine. However, a moderate increase in nasal sensitivity was noted after 7 days of Cimetidine treatment. Nasal sensitivity after 7 days of Cimetidine treatment was significantly greater than that after Famotidine treatment.We conclude that in patients with nasal allergy and peptic ulcer Famotidine is preferable to Cimetidine for the treatment of digestive tract disorders.
耳鼻咽喉科臨床学会の論文