Mycobacterium fortuitum呼吸器感染症の臨床像 : 国立療養所非定型抗酸菌症共同研究班

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Nine cases (8 pulmonary disease and I pleural empyema) of the respiratory disease due to Mycobacterium fortuitum were found in 5 of 13 National sanatoria in Japan during the period from January 1967 to August 1980. It was supposed that the respiratory disease due to M. fortuitum occupied about 1 per cent of whole atypical mycobacteriosis and the patients were found all over the country. The patients previously reported in Japan were all over 40-year-old and the patients found in National sanatoria were all over 50-year-old, while patients under 20 years of age have been found not rarely in Europe and America. There were no difierence in the number of patient by sex (5 men and 4 women). Subjective symptoms such as fever, cough, sputum and hemoptysis were observed at the onset of the illness in the majority of the patients. The disease was divided into two types; i.e., the primary infection type without underlying respiratory disease and the secondary infection type with preexisting disease. Three of 9 cases belong to the primary infection type. In the remaining 6 cases which belong to the secondary infection type, plumonary tuberculosis, pleurisy and pneumoconiosis was observed as the underlying disease, but there was no association of achalasia which was found frequently in European and American patients. In the primary infection type sputum culture negative conversion occurred in all cases by antituberculous drug therapy alone and the appearance of their chest X-ray improved, although all strains isolated from the patient were completely resistant to all antituberculous drugs. On the contrary, in the majority of the secondary infection cases the excretion of organisms from sputum continued for extended periods. No patient underwent any surgical treatment. Two patients have died during this period, but both patients died of the disease other than atypical mycobacteriosis.
日本結核病学会の論文

<I>Mycobacterium fortuitum</I>呼吸器感染症の臨床像 : 国立療養所非定型抗酸菌症共同研究班

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