Minocyclineの抗結核菌作用 (試験管内実験)

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In vitro antituberculous action of minocycline hydrochloride was studied using the H37Rvstrain of Mycobacterium tuberculosis and 23 strains isolated from tuberculous patients. Minocycline inhibited growth of the H37Rv strain on the Ogawa egg medium at a concentration of 2 μg/ml, when small inoculations composed of 18 to 92 viable units were used (Table1). Only a streptomycin-resistant strain isolated from the H37Rv by ‘one step-selection’ with1, 000 pg of streptomycin per ml tended to show a little higher resistance (Table 1). Minocycline inhibited growth of M. tuberculosis strains isolated from patients at concentrationsof 2.5 to 5 μg/ml (Table 2). Bactericidal activities of various antituberculous agents were compared with the actionof minocycline. The bactericidal action showed, from the strongest, the following order: Isoniazid, rifampicin, streptomycin and minocycline (Fig. 1). Bactericidal activity to killmore than 70% of organisms after contract with agent for 24 hours was 0.1μg for isoniazidperml, 1μg for rifampicin per ml, 1μg for streptomycin perml, respectively. Minocyclinedid not show such activity even at a concentration of 10μg/ml. However, slight bactericidalactivity was shown also in this agent (Fig. 1). For testing the bactericidal activity of minocycline, both 6-day-old and 14-day-old cultureswere used. The growth phase of these cultures are shown in Fig. 2. No significant differencewas observed between these two cultures as to the bactericidal action of mynocycline. In conclusion, minocycline showed considerable bacteriostatic activity on M. tuberculosis. It may be useful for chemotherapy of tuberculosis as an accessory agent.
日本結核病学会の論文

Minocyclineの抗結核菌作用 (試験管内実験)

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