多剤抗結核剤耐性肺結核症患者への治療の試み : 第1報デメチル・クロルテトラサイクリン〔レダマイシン(米国レダリー社)〕の抗抗酸菌作用について

概要

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In order to find out the effective treatment for pulmonary tuberculosis patients showing multiple resistance to anti-tuberculous drugs, the authors have been testing the anti-tuberculous activity of various antibiotics sold at the market. It was found that demethyl-tetracycline showed anti-tuberculous activity, and the following experiments were conducted.<BR>In the first experiment, the minimum inhibitory concentration M IC of LM (demethylchlortetracycline)to M. tuberculosis and other mycobacteria was measured. It was revealed that the MIC of LM to M. tuberculosis was 25mcg/m<I>l</I>, and LM was effective to various mycobacteria. The growth of M. avium and M. abscessus was not inhibited by LM, while M. intracellulare and M. fortuitum were susceptible to LM.<BR>In the second experiment, the combined effect of LM with other anti-tuberculous drugs was tested. It was found that the combined effect of LM was demonstrated exclusively with EB for M. tuberculosis and other mycobacteria.
日本結核病学会の論文