マウスの結核菌感染に対するOrotic acidならびに4-Amino5-imidazolecarboxamideorotateの効果

概要

論文の詳細を見る
Since Schwartz et al, reported that 6-mercaptopurine suppresses antibody formation, many papers appeared reporting on inhibition of immune response by purine analogues. In the field of experimental tuberculosis, Arima et al. stated that sensitization of rabbits by killed tubercle bacilli was suppressed by 6-mercaptopurine. In contrast to the above papers reporting effectiveness of purine analogues, Tsukamura et al. reported that adenine itself is able to modify infection of mice with tubercle bacilli. It was thus desirable to obtain further informations on biological effects of nucleic acid precursors. The purpose of the present paper is to report on the effect of orotic acid and 4-amino-5-imidazolecarboxamide orotate on infection of mice with tubercle bacilli.
日本結核病学会の論文