珪肺結核の治療に関する臨床的研究

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According to the review of the past literatures, the chemotherapy for silico-tuberculosis in the earlier days was almost unsuccessful. The present paper reports the follow-up studies of all the originally or retreated cases with silicotuberculosis, 140 in number, admitted to our hospital during the past 28 years (1953-1980). The results were summarized as follows: 1. Fourty-three previously untreated cases with positive sputum for tubercle bacilli, were treated with the combination of primary antituberculous drugs, SM, INH, and PAS. The negative conversion of tubercle bacilli in sputum was seen in 40 cases (93.0%), however, the bacteriological relapse was observed in 11 cases (27.5%) within three years. 2. Sixty-one previously treated cases with positive sputum for tubercle bacilli, were treated with regimens containing primary and/or secondary antituberculous drugs. Only 30 cases (49.2%) converted to negative, while the others showed continuous bacilli discharge. 3. The rate of bacteriological relapse before the introduction of RFP was higher in silico-tuber culosis than in tuberculosis of similar extent without complicating silicosis. These results indicate that bacteriological relapse is the important factor causing clinical aggravation of the disease. 4. The effects of intensive chemotherapy regimens containing RFP at the initial stage of treat ment were studied in 26 originally treated cases. The negative conversion of tubercle bacilli in sputum was reached revealed in 100% of cases within 5 month and continued until 34th month on the average after starting chemotherapy. 5. It is conceivable that an intensive chemotherapy regimens containing RFP for originally treated cases makes it possible to control and cure silico-tuberculosis as well as to shorten the duration of chemotherapy.
一般社団法人日本結核病学会の論文

珪肺結核の治療に関する臨床的研究

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