偶発的に微量に検出された結核菌の意義 (偽陽性について)

概要

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Among the outpatients of a certain hospital in Tokyo, mycobacterium tuberculosis colonies fewer than ten were isolated sporadically from single sputum specimens from 3 patients with non tuberculous pulmonary disease and 6 patients with inactive pulmonary tuberculosis, and sputum culture thereafter were contineously negative for a long period.<BR>The majority of such few colony isolates were found on days when the sputum specimens from the patients with smear positive tuberculosis or the specimens from which a large number of colonies were isolated, were cultured.<BR>The frequency of these few colony isolates was investigated. It was higher on days when smear positive specimens were cultured than on other days.<BR>From the results mentioned above, it is suggested that there is a possibility of cross contamination between smear positive sputum specimen and culture negative specimen.<BR>However, when a few colony is isolated from a single specimen, rare cases of pulmonary tuberculosis with normal chest radiographs should not be disregarded.
日本結核病学会の論文