Experimental study on efficacy of cimetidine, 16,16-dm PGE2 and vagotomy exerted to hepatic regeneration in prevention of stress ulcer after hepatectomy.

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The following conlusions were acquired after experimental study of the efficacy of cimetidine, 16, 16-dmPGE2, and vagotomy for hepatic regeneration in the prevention of stress ulcers after hepatectomy. (1) The onset of water stress ulcers was noticeably lessened in all three groups. (2) The number of cases of endocytosis after hepatectomy of 3H-thymidine decreased dramatically in the vagotomy group. The rate also decreased in the cimetidine and the 16, 16-dmPGE2 groups. The decreases were evident for thymidine kinase activity and the amount of DNA for all three groups. (3) The peak value in the mitotic indedx of the vagotomy group decreased, and the rate of hepatic regeneration was noticeably lower. We concluded from these three facts that the vagotomy operation is an inadequate treatment method for preventing stress ulcers after hepatectomy.
財団法人日本消化器病学会の論文