An experimental study of the action of dopamine in suppressing pentagastrin stimulated gastric acid secretion and its mechanism in rats.

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The action of dopamine (DA, 10μg/kg/min) on pentagastrin (16μg/kg/hr) stimulated gastric acid secretion was studied by use of Ghosh-Schild's rats. DA suppressed pentagastrin-stimulated gastric acid secretion 44.6 percent compared with the level before administration. This decrease in acid was inhibited by pretreatment with β1 and β1+β2 blockers and pretreatment with DA1+DA2 and DA1antagonists. The gastric acid secretion with DA1 agonist decreased 36.4 percent from the level at the time of pentagastrin administration. This decrease was inhibited by pretreatment with β1 blocker, but suppression of gastric acid secretion by β1+β2 stimulator was not inhibited by pretreatment with DA1antagonist. These results suggest that DA stimulated β1, adrenalin receptor via DA1 receptor and thereby suppresses pentagastrin-stimulated agstric acid secretion.
財団法人日本消化器病学会の論文