閉塞性黄疸時の急性潰瘍発生機序に関する実験的研究

概要

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To study the pathogenesis of acute ulceration in obstructive jaundice, rats were used to produce obstructive jaundice, and intra gastric pH, serum gastrin, secretin, gastric mucosal norepinephrine, gastric wall blood flow, gastric mucosal mucoid substance and gastric mucosal prostaglandin E_2 were measured in the groups of jaundice alone and jaundice + water immersion restraint stress. From the results of measurements, with the persistence of obstructive jaundice, gastric mucosal norepinephrine is first decreased, circulatory disorder appears in the gastric mucosa, with decrease in the gastric mucosal mucoid substance, and further excessive acidity seems to be involved. If stress is added to these states, from the early period of loading, cirulatory disorder appears in the gastric mucosal, and it seems'to become the main cause to form ulceration easily.
神戸大学の論文