障害肝切除後の急性上部消化管出血に関する実験的研究 : 主として血中凝固・線溶および局所線溶動態について

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Using liver cirrhosis rats, 70% hepatectomy were performed, and the participtation of coagulative and fibrinolytic activities at the onset of ulcer was studied. In the group of liver cirrhosis coagulation factors decreased, fibrinolysis in blood and the local gastric mucosa increased on the 1st〜3rd day after hepatectomy. However, no ulceration was noted in the gastric mucosa. Further, when water immersion restraint stress was loaded on the 3rd day after hepatectomy, liver cirrhosis group showed markedly increase of ulcer index earlier than control group. After loading stress fibrinolysis in blood and tissue increased markedly, corresponding nearly to the in crease of ulcer index. From the above, at the time after hepatectomy in liver cirrhosis temporary, increasing of fibrinolysis is present due to the decrease of hepatic functional reserve for hepatectomy, if stress is loaded under this condition fibrinolysis in blood increased further, coagulation factors decreased, and the occurrence of acute gastric ulcer was observed. Local fibrinolysis of the gastric mucosa was considered not only to become a factor for the occurrence of ulcer, but also to act as a factor for the aggravation of ulcer.
神戸大学の論文