急性膵炎時の胃病変発生機序についての実験的研究

概要

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The authors prepared models of acute pancreatitis using rats and studied the developmental mechanism of acute gastric ulcer accompanying acute pancreatitis, especially relating to fluctuations in the gastric wall blood flow and gastric movement. The following results were obtained. 1. When trypsin was injected into the pancreatic duct from the terminal end of the common bile duct, severe hemorrhagic necrotic pancreatitis was initiated in an early stage. 2. Three hours after the trypsin injection, independent erosions were noted in the antrum and duodenum, but no fluctuations in the blood pressure and gastric pH were observed in this period. Since ulceration was also noted in rats after truncal vagotomy, this is believed to be related to the pathological state of pancreatitis. 3. In the trypsin group, coinciding with the occurrence of ulcer, the obvious blood flow in various parts of the stomach was reduced and significant movement excitation in the antrum and duodenum were observed from an early stage. Coinciding with these changes, the gastric mucosal uronic acid also decreased significantly. 4. The development of acute gastric ulcer accompanying acute pancreatitis differs from that of the so-called stress-induced ulcer, and is believed to be caused by effects characteristic of acute pancreatitis.
神戸大学の論文