運動ストレスに関する研究-1-運動負荷における種々のヒト血漿酵素活性の変動について

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Eleven healthy untrained male students were studied, using a bicycle ergometer, 920kpm/min for 30min, to observe the effects of physical exercise upon the activities of various plasma enzymes. The enzymes examined were glutamic oxaloacetic transaminase (GOT) isozyme (mitochondrial GOT, m-GOT and soluble GOT, s-GOT), glutamic pyruvic transaminase (GPT), malate dehydrogenase (MDH), lactate dehydrogenase (LDH) isozyme (heart-type, H and muscle type, M), α-hydroxybutyric acid dehydrogenase (α-HBDH), creatine phosphokinase (CPK) isozyme (MM-, MB- and BB-type), aldolase, α-glutamyl transpeptidase (γ-GT), isocitrate dehydrogenase (ICDH), ornithine carbamoyltransferase (OCT), and dopamine-β-hydroxylase (DBH). Blood samples were drawn at the beginning and end of the exercise periods and then 20min, and 1, 6, 24 and 48 hours later.The results obtained were as follows:1) DBH activity increased after the end of exercise as well as during the 48-hour recovery period.2) The activities of skeletal muscle enzymes-m-GOT, s-GOT, LDH-M, CPK-MM, MDH, and aldolase-increased after exercise ended. LDH-M activity tended to increase after the 48-hour recovery period.3) Both cardiac muscle enzymes, α-HBDH and CPK-MB, increased in activity after exercise was terminated. LDH-H activity decreased after the 48-hour recovery period.4) After exercise ended, the activities of hepatic enzymes, such as ICDH and GPT, tended to increase. γ-GT increased and OCT activity decreased after the recovery period.The results demonstrate that even enzymes from the same organ reacted differently to physical exercise. Moreover, the results suggest that the prolonged liver dysfunction can be associated with increased sympathetic nerve activity.
日本衛生学会の論文

運動ストレスに関する研究-1-運動負荷における種々のヒト血漿酵素活性の変動について

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