Bacterial Aerosol に関する研究 : 第9報健康被験者から飛散した空中ブドウ球菌の抗生物質感受性

概要

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Two hundred and four strains of airborne staphylococci from healthy human subjects were tested for their biological properties and susceptibility to novobiocin. They were then classified into three groups based on the results of such tests. In addition, susceptibility to each of the major antibiotics-penicillin G, methicillin, cloxacillin, erythromycin, chloramphenicol, streptomycin and tetracycline-was tested. The results obtained were as follows:1. Five strains were coagulase-positive. These were identified as Staphylococcus aureus (S. aureus). The remaining 199 coagulase-negative strains were further classified into S. epidermidis (171 strains) and S. saprophyticus (28 strains) according to novobiocin susceptibility.2. Airborne S. aureus strains showed marked differences in minimal inhibitory concentration (MIC) for penicillin G when compared to standard S. aureus strains (e. g. FDA209P).3. Most airborne S. epidermidis strains had characteristic MIC values for each antibiotic except penicillin G. The number of strains resistant to the antibiotics tested was low for airborne S. epidermidis when this number was compared to the clinical isolates described elsewhere (Pulverer and Jeljaszewicz, 1973; Shimizu et al., 1977).4. Nineteen of the S. saprophyticus strains were resistant to methicillin and novobiocin, and they appeared to be more virulent than the remaining novobiocin-susceptible strains.