ラット肝における5β型ステロイドの生成に及ぼす砒酸カルシウムの影響

概要

論文の詳細を見る
It has been observed that a disturbance in heme biosynthesis, especially the increase of urinary δ-aminolevulinic acid can be caused by arsenic poisoning, as well as by lead and mercury poisoning. The mechanism of this action, however, has not yet been clearly explained. In the following experiment, the formation of 5β type steroids which induce δ-aminolevulinic acid synthetase was studied by measuring the changes in the activities of steroid 5β-reductase, 3α- and 3β-hydroxysteroid dehydrogenase and β-D-glucuronidase. In order to measure these changes, 105, 000×g supernatant and lysosome of the liver of the rat were used as enzymes.On the seventh day after the subcutaneous administration of calcium arsenate, the activities of testosterone, Δ4-androstene-3, 17-dione, progesterone and 17α-hydroxy progesterone 5β-reductase increased significantly, and also those of 3α-hydroxysteroid dehydrogenase with androsterone and 5β-pregnan-3α-ol-11, 20-dione as substrate showed a significant increase. No significant difference, however, was observed in the activities of 3β-hydroxysteroid dehydrogenase and β-D-glucuronidase.On the fourteenth day after the subcutaneous administration of calcium arsenate, no significant difference was observed in the activities of steroid 5β-reductase, 3α- and 3β-hydroxysteroid dehydrogenase and β-D-glucuronidase.From these results, it is suggested that at the beginning of arsenic poisoning some 5β type steroids increase, and play a role in bringing about the increase of δ-aminolevulinic acid.
日本衛生学会の論文

ラット肝における5β型ステロイドの生成に及ぼす砒酸カルシウムの影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク