ラット肝の steroid 5β-reductase 活性に対する酢酸第二水銀の影響

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The increase of urinary δ-aminolevulinic acid in man and animals exposed to high concentration of mercury is studied, but the mechanism of the increase has not been clearly explained. In this paper, the content of 5β type steroid, inducing δ-aminolevulinic acid synthetase, was studied by noticing the activities of steroid 5β-reductase, which is the rate limiting enzyme in metabolism of steroid hormones, 3α- and 3β-hydroxysteroid dehydrogenase. For measurement of these activities, 105, 000×g supernatant of rat liver was used.The testosterone and Δ4-androstene-3, 17-dione 5β-reductase activities decreased on either the fourth or eleventh day after either intraperitoneal or subcutaneous administration of mercuric acetate, respectively, and the adrenosterone 5β-reductase activity increased on the eleventh day after the subcutaneous administration of mercuric acetate. These changes mentioned above, however, were not significant.The progesterone and 17α -hydroxy progesterone 5β-reductase activities decreased on either the fourth or eleventh day after either intraperitioneal or subcutaneous administration of mercuric acetate, but there were no significant changes. The Δ4-pregnen-20β-ol-3-one 5β-reductase activity decreased significantly on the fourth day after the intraperitoneal administration of mercuric acetate.The 3α -hydroxysteroid dehydrogenase activity on etiocholanolone decreased significantly on the fourth day after the intraperitoneal administration of mercuric acetate, but that on androsterone and epipregnanolone did not show any significant change after administration of mercuric acetate. No significant change was observed in the 3β-hydrogysteroid dehydrogenase activity on epiandrosterone with the administration of mercuric acetate.From these results, it was said that in mercury poisoning the increase of 5β type steroids was not verified and δ-aminolevulinic acid synthetase activity in heme synthesis was little affected by 5β type steroids.
日本衛生学会の論文

ラット肝の steroid 5β-reductase 活性に対する酢酸第二水銀の影響

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