B型肝炎ウイルスワクチンによるHBs抗体responseの長期観察と抗体産生のメモリーについて

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We studied the long-term outcome of hepatitis B (HB) vaccination. Anti-HBs response to booster injection was determined in 41 vaccine recipients, whose anti-HBs titers were below 23 by PHA at the end of the follow-up period. 116, who were seronegative for both HBsAg and antiHBs by RIA, received the HB vaccine contained 20μg of HBsAg at 0, 4 and 24 weeks. During the period 1981 to 1982, in May 1984 and August 1985, a further investigation was carried out (156 week in average). Seroconversion rate to anti-HBs increased 79.3% within 28 weeks at just after the last vaccination. However after a 156 week follow-up period, anti-HBs disappeared in 25, making the seroconversion rate 57.7%, Anti-HBs titers increased with each succeeding inoculation and then decreased during the follow-up period in all vaccinees except one, who seemed to have had a natural infection of HB virus. After a single booster injection a brisk rise of anti-HBs was observed in all of the 18 responders, because of anamnestic response. 70% of low responders and 23.1% of no responders developed anti-HBs respectively. Anti-HBs titers did not remain at a protective level in some vaccinees during the follow-up period. Therefore, booster injections are necessary whenever anti-HBs titers fall below protective level, with a regular follow-up. A single booster is sufficient within the follow-up period since memory of immunization seems to remain in responders.
社団法人日本肝臓学会の論文

B型肝炎ウイルスワクチンによるHBs抗体responseの長期観察と抗体産生のメモリーについて

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