慢性肝疾患におけるヘパト-マ発生について-1-肝硬変59例のProspective study

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The incidence of hepatoma developed on the ground of liver cirrhosis has been observed at high incidence frequency, particularly in those cases with history of viral hepatitis, and such association has been regarded important clinically. This time, we performed a prospective study of 59 cases with liver cirrhosis during the period from April 1973 to August 1975, and investigated the role of Hepatitis B Virus (HBV) on the development of hepatoma.<BR>The cases were divided into 3 groups i.e. HBs-Ag positive (16 cases), anti HBs positive (10caSes)and bothegative(33 cases). We followed up serum α-Fetoprotein periodically by RIA method. In 4 cases with positive HBs-Ag, we observed gradual increase of α-Fetoprotein, and tumor stains were demonstrated with celiac angiogram. The high rate of hepatoma in this group is significantly different from those of the other two groups. The tumors were solitary and multiple in each two cases and surgical resection could be done in each one of them. We affirmed two cases of small hepatoma of histologically Edmondson Group II, all were less than 2 cm in diameter and might be early hepatoma.<BR>In all of the four cases, the presence of HBs-Ag in serum and hepatocyte were found before the development of hepatoma. It implicates a close relationship between the incidence of hepatoma and HBV or HBs-Ag.
社団法人日本肝臓学会の論文