ヒト肝癌培養細胞におけるPIVKA-IIの減少からみたメナキノン-4とメナキノン-7の効果の比較

概要

論文の詳細を見る
Effects of menaquinone (MK)-4 and -7 were examined using human hepatoma cell line (huH-2), which produced PIVKA-II in the culture medium. The production of PIVKA-II increased in a time- and cell concentration- dependent fashion. As vitamin K was added to the culture medium, the production of PIVKA-II decreased in parallel with increasing vitamin K concentrations. Although no changes were shown in F-II RAG fraction after the addition of vitamin K, the F-II RAG fraction became to have a coagulant activity. Accordingly, when effects of the vitamin K derivatives, MK-4 and -7, were examined on the basis of the decrease rate of PIVKA-II fraction in the huH-2 cell line, MK-7 was found to have a greater effect as compared with MK-4.
日本ビタミン学会の論文
1989-06-25