潰瘍性大腸炎の活動期における顆粒球吸着療法 : 多施設共同無作為割付比較試験

概要

論文の詳細を見る
A clinical study was undertaken in patients with active ulcerative colitis (UC, n=53) to evaluate the therapeutic benefit of granulocsyte and monocyte apheresis with the G-1 column and compare the usefulness of this treatment with that of standard medication for UC (n=52). Patients in the G-1 group underwent a total of 5 aphereses, each of one-hour duration, over 5 weeks ; patients in the standard medication group were treated in accordance with the guidelines of the Reseach Committee of Inflammatory Bowel Disease, the Japanese Ministry of Welfare and Therapy Group. At the end of the treatment course, the clinical usefulness of the G-1 column was determined to be 58.8% and that of standard medication was 44.2% (ρ=0.045). Further, patients who were found to be steroid resistant (severe stage, intractable, disease duration >__=5.3 years ; total steloid administered >__=10g and CRP >1.8 mg/dL) responded more favourably to granulocyte and monocyte apheresis compared to standard medication (steroid therapy). The results of this multicentre study suggest that patients with UC may benefit from granulocyte and monocyte apheresis and that the G-1 column apheresis system is superior to standard steroid regimens.
日本アフェレシス学会の論文
1999-02-28