B型慢性肝炎に対するインターフェロン療法の長期予後とprecore変異との関連

概要

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Twenty-seven patients with hepatitis B (HB) e-antigen positive chronic hepatitis B were treated with interferon and followed up for 36 to 108 months after cessation of interferon treatment. In 20 (74%) of the patients, HBe-antigen was seroconverted to anti-HBe antibody. Among patients seroconverted from HBe-antigen to anti-HBe antibody, the normalization of serum aminotransferase and disappearance of HBV-DNA from sera occurred in 17 (63%) of the patients. Pre-treatment with steroid and the duration and amount of interferon treatment were unrelated with the effectiveness of the treatment. To study the susceptibility of HB-virus strain with precore mutant to interferon treatment, the sequence at nt. 1986 resulting in a stop codon of the precore region was analyzed by mutation site specific assay (MSSA). The precore sequence was precore mutant strain was as sensitive to interferon as the precore wild type strain. However, from the present findings, viral quantity right after interferon treatment was fairly informative for predicting the long-term outcome.
東京女子医科大学の論文
1998-04-25