HLA antigens and anti-HBs response to hepatitis B vaccine.

概要

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To investigate whether the anti-HBs response to the hepatitis B vaccine is genetically determined or not, the HLA antigens were examined in 167 vaccine recipients. The vaccine recipients were divided into five groups according to the time of acquiring of anti-HBs (early responder: 41 cases, late or no responder: 36 cases, no responder: 23 cases) and the titer of antiHBs (high responder: 32 cases, low or no responder: 41 cases).<BR>Bw39 (22.0%) and Cw7 (43.9%) in the early responder were statistically significant in frequency (Pc<0.02 and Pc<0.007 respectively). The frequency of Bw52 and DRw9 in the late or no responder and also in the no responder were found to be significantly higher than that in normal controls. B7 (34.4%) Cw7 (46.8%) and MT1 (93.7%) in the high responder were statistically significant in frequency (Pc<0.002 Pc<0.007 Pc<0.03 respectively). The frequency of Bw52 in the low responder was found to be higher than that in normal controls.
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