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In the present study, the Natural Killer Activity of peripheral blood lymphocytes to cultured cell line target (huH-2) of hepatocellular carcinoma in origin was revealed to be slightly higher in asymptomatic HBsAg carrier (ASC) and slightly lower in chronic hepatitis (CH, 19 cases) as compared to normal subjects (18 cases). A significant decrease of Killer activity was, on the other hand, demonstrated in liver chrirrosis (LC, 14 cases, p<0.05) and hepatocellular carcinoma (HCC, 15 cases, p<0.001). The addition of Poly I:C and interferon produced a significantly increased Killer activity with the order of ASC, CH, and HCC. Killer cells against cultured cell line target cells (huH-2) was strongly suggested to be of natural killer cells by means of cold target inhibition test and discontinuous Percoll density gradient centrifugation.
社団法人日本肝臓学会の論文