LE細胞、抗核抗体陽性を呈したPost-infantile giant cell hepatitisの1例

概要

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A 41-year-old woman was admitted to our hospital with jaundice and general fatigue. Liver function tests revealed elevation of total bilirubin and transaminase with marked gammaglobu- linemia. Serum antinuclear antibody, anti-DNA antibody and LE cell were positive. All viral markers were negative.<BR>Predonisolone, 40mg/day was prescribed and a rapid improvement was observed in transaminase, total bilirubin and gammaglobulin. 141 days later, liver biopsy was performed, which revealed marked multinucleated giant cell infiltration. Multinucleated giant cell transformation is a common histological feature of several types of liver disease in the neonatal period. However, the presence of a number of Multinculeated giant cells in the liver is rare, later in life. It is noteworthy that Post-infantile giant cell hepatitis occurred in association with positive of LE cell, antinuclear antibody.
社団法人日本肝臓学会の論文