C型肝炎ウイルスの遺伝子の型分類とその臨床的意義

概要

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Hepatitis C virus (HCV) in Japan can be divided into the 4 genotypes, PT, K1, K2a, and K2b. However, clinical significance of the types of HCV is not well known. In the present study, genotyping of HCV was carried out in serum samples obtained from 71 Japanese, 12 Spanish and 11 Chinese with HCV related liver disease, using two different methods. In 58 non-cancer Japanese patients, K1 was 44 (75.9%), K2a was 9 (15.5%), and K2b was 4 (6.9%). PT was found in only one patient (1.7%) whose, hepatitis developed after transfusion of factor VIII preparation imported from the U.S.A. In 13 patients with hepatocellular carcinoma, K1 was found in 11 (84.6%). In particular, all alcoholic patients were positive for K1. In Spanish patients, K2 was not found in any cases. The prevalences were 38.5% (5 cases) for PT and 53.8% (7 cases) for Kl. In Chinese patients, the prevalences were 54.5% (6 cases) for K1, 36.4% (4 cases) for K2a, and 9.1% (1 case) for K2b. PT was not found in any cases. Thus, prevalences of HCV genotypes were quite different among the countries. These results suggest that the original type of HCV may be K1, and that PT may be a variant of the Western type, and K2 may be a variant of the Oriental type. These differences in the prevalences of the HCV types may be related to the difference of clinical features of HCV related liver diseases among the countries.
社団法人日本肝臓学会の論文