グルカゴン負荷試験の基礎的検討

概要

論文の詳細を見る
Plasma cyclic AMP (c-AMP) levels after administration of different doses (1, 5, 10 and 20μg/kg) of glucagon were determined to simplify and standardize the glucagon test for the evaluation of the hepatocellular function. The clearest reactions of plasma c-AMP were observed after 10μg/kg of glucagon administration. Correlations between various liver function tests which reflect total hepatic functioning cell masses and plasma c-AMP levels were the closest at 10 minutes after administration of 10μg/kg of glucagon. In the 10μg/kg loading, the peak value for plasma c-AMP was obtained between 10 and 15 minutes after glucagon administration. However, there was no significant difference between 10 and 15 minutes values. The closest correlation between the liver function tests and plasma c-AMP levels was obtained in the 10 minutes value, but not 15 minutes. These results indicated that determination of 10 minutes or peak values for plasma c-AMP after 10μg/kg loading was the most simple and suitable procedure for a glucagon test.
社団法人日本肝臓学会の論文