Clinical significance of serum prolyl hydroxylase .BETA.-subunit levels determined using monoclonal antibody.

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Serum immunoreactive prolyl hydroxylase β-subunit (IR β-PH) levels were measured using monoclonal antibodies in various liver diseases and the levels were compared with serum procollagen type III N-terminal peptide (Pro-III-N-P) leveles. In almost all cases of chronic hepatitis and liver cirrhosis, serum IR β-PH levels were significantly elevated and tended to increase parallel to the degree of activity of hepatitis. Serum Pro-III-N-P levels showed nearly the same changes as those of IR β-PH in chronic hepatitis and cirrhosis. However, serum Pro-III-N-P levels were increased in almost all cases of acute hepatitis and metastatic liver cancer, but serum IR β-PH levels were in the normal range in metastatic liver cancer and elevated in only half of the cases of acute hepatitis. Although the correlation between serum IR β-PH and Pro-III-N-P levels was statistically significant in all cases of liver diseases, significant correlation was observed in only a few deseases. These results indicated that serum IR β-PH reflected more selectively the synthesis of heaptic collagen than Pro-III-N-P and that serum IR β-PH is one of the most sensitive markers of the hepatic fibrogenesis.
財団法人日本消化器病学会の論文