Differences in changes of two serum markers of hepatic fibrogenesis in acute hepatitis.

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概要

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• The serum levels of immunoreactive prolyl hydroxylase β-subunit (IRβ-PH) and procollagen type III N-terminal aminopeptide (Pro-III-N-P), which have been generally considered to be markers of hepatic fibrogenesis, were measured in acute hepatitis (AH) in order to clarify the differences between the markers for the evaluation of hepatic fibrogenesis. The mean values of both serum marker levels of AH were significantly higher than those of the normal controls. Serum Pro-III-N-P levels were abnormally high in almost all cases of AH. Only half of the AH cases, however, showed abnormally high serum IRβ-PH levels. In almost all cases of AH, serum IRβ-PH levels decreased to nearly normallevels within 3 weeks of admission and retained normal values throughout the healing course. However, serum Pro-III-N-P levels remained abnormally high in many AH cases. These results indicated that serum IRβ-PH levels were more specific than serum Pro-III-N-P for the evaluation of collagen synthesis in the liver.

• 財団法人 日本消化器病学会の論文

著者

• 安原 稔

  金沢医科大学消化器内科

関連論文

• Differences in changes of two serum markers of hepatic fibrogenesis in acute hepatitis.
• Clinical significance of serum prolyl hydroxylase .BETA.-subunit levels determined using monoclonal antibody.

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