L-Dopa Potentiates Presynaptic Inhibitory .ALPHA.2-Adrenoceptor- but Not Facilitatory Angiotensin II Receptor-Mediated Modulation of Noradrenaline Release from Rat Hypothalamic Slices.
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概要
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L-Dopa is a potentiator for presynaptic β-adrenoceptors. We studied whether L-dopa potentiates the activities of other presynaptic receptors to modulate the evoked noradrenaline (NA) release in rat hypothalamic slices. UK14304 (0.1-1 μM), a selective α<SUB>2</SUB>-agonist, concentration-dependently inhibited NA release. Noneffective 10 pM L-dopa potentiated the UK14304-induced inhibition. This potentiation was selectively antagonized by 1 nM L-dopa methyl ester, a competitive L-dopa antagonist, while yohimbine antagonized both the inhibition by UK14304 alone and its potentiation by L-dopa. However, 10 pM L-dopa produced no effect on angiotensin II (0.1-1 nM)-induced facilitation. L-Dopa potentiates activities of presynaptic β- and α<SUB>2</SUB>-adrenoceptors but not those of angiotensin II receptors on rat hypothalamic NA neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Miyamae Takeaki
Deparment Of Molecular Pharmacology And Neurobiology Yokohama City University School Of Medicine
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Goshima Yoshio
Department Of Molecular Neuropharmacology Yokohama City University Graduate School Of Medicine
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Sato Kazuo
Department Of Mechanical Engineering Ii Shibaura Institute Of Technology
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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Sato Kazuo
Departments of Anaesthesiology, Yokohama City University School of Medicine
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Okumura Fukuichiro
Departments of Anaesthesiology, Yokohama City University School of Medicine
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Miyamae Takeaki
Departments of Pharmacology, Yokohama City University School of Medicine
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