Carteolol is a useful tool to prove the tonically functioning nature of presynaptic .BETA.-adrenoceptors on peripheral noradrenergic neurons but not on central catecholaminergic neurons.
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概要
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Effects of carteolol on norepinephrine (NE) release were studied at 2 Hz mainly in rat hypothalamic slices. Isoproterenol at 1 and 10 nM concentrationdependently facilitated NE release. Isoproterenol (10 nM)-induced facilitation was antagonized by 1 and 10 nM <I>dl</I>-carteolol, but not antagonized by 1 nM <I>d</I>-carteolol. <I>dl</I>-Carteolol alone at 1 nM to 10 μM did not inhibit NE release. In brainstem slices, 10 nM isoproterenol also facilitated NE release, and this facilitation tended to be antagonized by 1 nM <I>dl</I>-carteolol. Nanomolar concentrations of carteolol stereoselectively antagonized isoproterenol-induced facilitation of NE release via presynaptic β-adrenoceptors in rat hypothalamic slices.
- 公益社団法人 日本薬理学会の論文
著者
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Goshima Yoshio
Department Of Molecular Neuropharmacology Yokohama City University Graduate School Of Medicine
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Nakamura Shinichi
Department Of Anesthesiology Saitama Medical School
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OHNO Kaoru
Department of Developmental Biology, National Institute for Basic Biology
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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