Evidence for the existence of stereoselective presynaptic .BETA.1-adrenoceptors on noradrenergic and dopaminergic neurons in the rat hypothalamus.
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概要
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Using high performance liquid chromatography with an electrochemical detector, we examined antagonistic effects of <I>l</I>- and <I>d</I>-acebutolol and atenolol against isoproterenol-induced facilitation of impulse-evoked release of endogenous norepinephrine and dopamine in rat hypothalamic slices. Isoproterenol (10 nM) increased the release of the both catecholamines, and this facilitation was similarly antagonized by 100 nM <I>l</I>-acebutolol and 100 nM atenolol, but was not antagonized by 100 nM <I>d</I>-acebutolol. In conclusion, there exist stereoselective presynaptic β<SUB>1</SUB>-adrenoceptors on noradrenergic and dopaminergic neurons in the rat hypothalamus.
- 公益社団法人 日本薬理学会の論文
著者
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Goshima Yoshio
Department Of Molecular Neuropharmacology Yokohama City University Graduate School Of Medicine
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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CHANG Chia
Department of Neurological Surgery, Yokohama City University School of Medicine
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