Endogenously Released DOPA Is Probably Relevant to Nicotine-Induced Increases in Locomotor Activities of Rats.
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概要
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The relevance of endogenously released DOPA to the (±)-nicotine-induced increase in locomotor activities was explored in rats. This increase was dose (0.1-1.0 mg/kg, s.c.)-dependent, stereo-selective and mecamylamine (1.0 mg/kg, s.c.)-sensitive, but was not antagonized by L-dopa methyl ester (200 pg, i.v.t.), a competitive L-dopa antagonist. Then, by microdialysis, low doses of α-methyl-<I>p</I>-tyrosine (α-MPT, i.p.) at 1-10 mg/kg, were tested to find a dose that selectively inhibits the basal DOPA release in the striata: the release was consistently inhibited by 3 mg/kg without any tendency to inhibit the basal dopamine release. Pretreatment with this dose did inhibit the nicotine-induced increases in locomotor activities. This suggests that endogenously released DOPA is in part relevant to the nicotine-induced behavior in rats.
- 公益社団法人 日本薬理学会の論文
著者
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Miyamae Takeaki
Deparment Of Molecular Pharmacology And Neurobiology Yokohama City University School Of Medicine
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Yue Jin-liang
Department Of Pharmacology Yokohama City University School Of Medicine
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Goshima Yoshio
Department Of Molecular Neuropharmacology Yokohama City University Graduate School Of Medicine
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Nakamura Shinichi
Department Of Anesthesiology Saitama Medical School
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YUE Jin-liang
Department of Pharmacology, Yokohama City University School of Medicine
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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