Pharmacological properties of presynaptic .BETA.-adrenoceptors in guinea-pig pulmonary arteries.
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概要
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Pharmacological properties of the facilitatory presynaptic β-adrenoceptor mechanism were studied in superfused spiral preparations of guinea-pig pulmonary arteries preloaded with <SUP>3</SUP>H norepinephrine. (-) Isoproterenol (0.3 μM)-induced increases in total <SUP>3</SUP>H efflux per pulse evoked by transmural field stimulation (1, 5, 10 and 20 Hz, 10 V, 2 msec pulse width, 100 pulses and 30 min intervals) were neither dependent on impulse-frequencies nor selective at lower frequencies. Isoproterenol increased <SUP>3</SUP>H efflux at 5 Hz in a concentration-dependent manner (1 nM to 1 μM): pD<SUP>2</SUP> was 7.7. Salbutamol increased <SUP>3</SUP>H efflux in a similar manner to isoproterenol: pD<SUP>2</SUP> was 7.4. Prenalterol at 3 μM only slightly increased <SUP>3</SUP>H efflux. Tazolol (10 nM to 3 μM) produced no increases. Atenolol (3 μM) and practolol (3 μM) did not antagonize isoproterenol (0.3 μM)-induced increases in <SUP>3</SUP>H efflux. Butoxamine (3 μM) and H 35/25 (3 μM) did antagonize this parameter. (-)-Epinephrine (1 nM to 0.1 μM) decreased <SUP>3</SUP>H efflux at 5 Hz and concentration-dependently increased this parameter in the presence of 10 μM phentolamine. (-)-Norepinephrine (10 nM to 1 μM) concentration-dependently inhibited evoked <SUP>3</SUP>H efflux and did not increase the parameter in the presence of 10 μM phentolamine, 10 μM cocaine and 10 μM normetanephrine. Thus, there exist presynaptic β<SUP>2</SUP>-subtype receptors on noradrenergic nerve endings innervating guinea-pig pulmonary arteries.
- 公益社団法人 日本薬理学会の論文
著者
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Kubo Takao
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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Kuwahara Misako
Department Of Pharmacology Yokohama City University School Of Medicine
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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YASUDA Gen
The 2nd Department of Internal Medicine, Yokohama City University School of Medicine
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KAIHO Masayoshi
Department of Legal Medicine Faculty of Medicine, University of Tokyo
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