Electrical Stimulation-Evoked Release of Endogenous Taurine from Slices of the Hippocampus, Cerebral Cortex and Cerebellum of the Rat
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概要
- 論文の詳細を見る
Release of endogenous taurine by electrical stimulation of slices of the hippocampus, cerebral cortex, cerebellum and medulla oblongata of the rat was studied and compared with that of alanine and/or γ-aminobutyric acid (GABA). Electrical stimulation caused a calcium-dependent release of taurine from slices of the hippocampus, cerebral cortex and cerebellum but not from slices of the medulla oblongata. The stimulus-evoked release of taurine in the hippocampus was rapid in onset and declined to baseline fast, which was essentially similar to the time course pattern of the stimulusevoked release of GABA. In addition, there were distinct regional differences in the relative amounts of taurine released. Electrical stimulation did not release alanine from any regions examined. These results support the hypothesis that taurine plays a neurotransmitter role in the hippocampus, cerebral cortex and cerebellum of the rat.
- 公益社団法人日本薬学会の論文
著者
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Sato Masami
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Takano Akiko
Department Of Internal Medicine Ii Hokkaido University Graduate School Of Medicine
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Takano Akiko
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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KUBO Takao
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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Kubo Takao
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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TOKUSHIGE Natsuko
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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MIYATA Noriko
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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HATAKEYAMA Satoko
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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Sato Masami
Department Of Anesthesia Kyoto University Hospital
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Miyata Noriko
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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Tokushige Natsuko
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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Hatakeyama Satoko
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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Sato Masami
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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