Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism in guinea pig pulmonary arteries.
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概要
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We have attempted to clarify whether or not captopril and <SUP>1</SUP>Sar-<SUP>8</SUP>lle-angiotensin II could protect isoproterenol-induced facilitation of norepinephrine release in guinea pig pulmonary arteries loaded with <SUP>3</SUP>H-norepinephrine. Angiotensin I at 1 nM and 30 nM isoproterenol similarly facilitated evoked release of <SUP>3</SUP>H-norepinephrine at 1 Hz. Captopril at 1 μM and <SUP>1</SUP>Sar-<SUP>8</SUP>lle-angiotensin II at 10 nM completely prevented angiotensin I-induced facilitation, whereas these pretreatments produced no effect on isoproterenol-induced facilitation. Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism.
- 公益社団法人 日本薬理学会の論文
著者
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Kubo Takao
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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MISU Yoshimi
Department of Pharmacology, Yokohama City University School of Medicine
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Kuwahara Misako
Department Of Pharmacology Yokohama City University School Of Medicine
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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