Evidence for the Involvement of Platelet-Derived Growth Factor in the Angiotensim II-Induced Growth of Rat Vascular Smooth Muscle Cells
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概要
- 論文の詳細を見る
This study examines the possible involvement of endogenous platelet-derived growth factor (PDGF) in the angiotensin II-induced growth of rat aortic smooth muscle cells. In quiescent confluent cells, anti-PDGF-AB neutralizing antibody inhibited angiotensin II-induced DNA synthesis and protein synthesis. PDGF-AA, -AB, and -BB produced concentration-dependent increases in DNA synthesis and protein synthesis. Genistein did not inhibit PDGF-AB-induced [^3H]thymidine incorporation and [^3H]leucine incorporation. PDGF-AB stimulated mitogen-activated protein (MAP) kinases, and PDGF-induced MAP kinase activation was inhibited by genistein. Angiotensin II induced PDGF-A chain messenger RNA expression, and genistein inhibited angiotensin-induced PDGF gene expression. These findings suggest that endogenous PDGF is, at least in part, involved in angiotensin II-induced cell growth in rat vascular smooth muscle cells. It appears that genistein inhibits angiotensin II-induced DNA synthesis partly by inhibiting PDGF-A gene expression.
- 公益社団法人日本薬学会の論文
- 1999-02-15
著者
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HAGIWARA Yoshihide
Hagiwara Institute of Health
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Saito E
Department Of Pharmacology Showa College Of Pharmaceutical Sciences Machida
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Saito Emi
Department Of Food And Nutrition Japan Women's University
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Hanada Motoki
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KUBO Takao
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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Kubo T
Department Of Pharmacology Yokohama City University School Of Medicine
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Kubo T
Department Of Pharmacology Showa Pharmaceutical University
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Kubo Takao
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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KAMBE Toshie
Department of Pharmacology, Showa Pharmaceutical University
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HAGIWARA Yukihiko
Department of Pharmacology, Showa Pharmaceutical University
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HANADA Maki
Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida
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Kambe T
Department Of Pharmacology Showa Pharmaceutical University
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Hagiwara Yukihiko
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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Kambe Toshie
Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida
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