Effects of chlorpromazine in the nucleus reticularis lateralis on the cat cerebellar potentials.
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概要
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In the experiments reported here, we investigated chlorpromazine (CPZ)-induced enhancement of the cat cerebellar potentials evoked by peripheral nerve stimulation, with regard to the subtypes of adrenoceptor in the nucleus reticularis lateralis (LRN). Electrical stimulus of the locus coeruleus (LC) at high frequencies enhanced cerebellar potentials evoked by peripheral nerve stimulation. Although similar stimulus increased them after pretreatment with an α<SUB>2</SUB>-antagonist, yohimbine, these enhancements were not recognized by pretreatment with an α<SUB>1</SUB>-antagonist, prazosin. Microinjection of norepinephrine (NE: 10 μg) into LRN decreased cerebellar potentials, and conversely, 30 μg of NE significantly increased them. Although microinjection of an α<SUB>2</SUB>-adrenoceptor agonist, clonidine, into the LRN depressed cerebellar potentials, clonidine-induced decrease was obviously antagonized by pretreatment with CPZ. Furthermore, an α<SUB>1</SUB>-adrenoceptor agonist, phenylephrine, into the LRN increased cerebellar potentials. Pretreatment with CPZ hardly changed phenylephrine-induced enhancement. We thought that CPZ blocked α<SUB>2</SUB>-autoreceptors in adrenergic terminals from the LC rather than α<SUB>1</SUB>-adrenoceptors within the LRN. As a result, NE released from the LC terminals may act on α<SUB>1</SUB>-adrenoceptors in the LRN and may attenuate activities of the LRN. Therefore, it was clear that previous CPZ-induced enhancement may be due to depression of the descending inhibitory adrenergic system via CPZ-induced blockade of α<SUB>2</SUB>-autoreceptors.
- 公益社団法人 日本薬理学会の論文
著者
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Suzuki Yukiko
Department Of Internal Medicine Kitasato Institute Hospital
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Hagiwara Yukihiko
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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SUZUKI Yukiko
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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