Interaction of prostaglandin E2 and bradykinin in the induction of afferent splanchnic nerve discharges in cats.
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概要
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In anesthetized cats, the administration of either bradykinin (BK) (0.3-3 μg/kg) or prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) (1-30 μg/kg) into the cranial mesenteric artery dose-dependently evoked the firing discharge in the proximal end of the afferent greater splanchnic nerves with a latency of about 10 sec, the pronounced contraction of the longitudinal muscle of the jejunum, and changes in blood pressure. PGE<SUB>2</SUB> at the doses of 1-10 μg/kg i.a. potentiated the BK (1 μg/kg i.a.)-induced firing discharge of the afferent splanchnic nerves of which latency was also shortened, but did not alter the BK-induced jejunal contraction and blood pressure change. However, trimoprostil (30 μg/kg i.a.), a trimethyl PGE<SUB>2</SUB> derivative, did not change all of these responses to BK. Aspirin at 50 mg/kg i.v. markedly prevented the BK-induced nerve discharges, but not the BK-induced jejunal contraction. These results taken together indicate that PGE<SUB>2</SUB> may be involved in the facilitatory response of afferent splanchnic nerve discharges to BK, but not involved in the BK-induced jejunal contraction and blood pressure change. The findings on trimoprostil present the possibility that derivatization of PGE<SUB>2</SUB> could modify its inherent ability to produce adverse side-effects.
- 公益社団法人 日本薬理学会の論文
著者
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Yajima Takashi
Department Of Internal Medicine Musashino Red-cross Hospital
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Ohno Tomochika
Department Of Applied Pharmacology Kyoto College Of Pharmacy
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Nakamura Keiji
Department Of Biology And Geosciences Graduate School Of Science Osaka City University:present Addre
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URANO Toshihiro
Department of Pharmacology, Nippon Roche Research Center
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OHNO Tomochika
Department of Pharmacology, Nippon Roche Research Center
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