EFFECTS OF SOME DRUGS ON THE γ-AMINOBUTYRIC ACID TRANSAMINASE AND THE SUCCINIC SEMIALDEHYDE DEHYDROGENASE OF RAT BRAIN
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概要
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The distribution of γ-aminobutyric-α-ketoglutaric acid transaminase and DPN-linked succinic semialdehyde dehydrogenase in 7 areas of rat brain was determined. Both enzyme activities vary with the age of the animal. The activity of both enzymes in the different brain areas roughly parallels the concentration.<BR>Estimations of enzyme activity in various parts of the brain taken from animals pretreated with either pentobarbital, diphenylhydantoin or trimethadione show a depression of activity of both enzymes the extent of which vary in different parts. The drugs in concentrations which are present in the brain when added to the enzymes <I>in vitro</I> do not inhibit them.
- 公益社団法人 日本薬理学会の論文
著者
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Nakamura Keiji
Department Of Biology And Geosciences Graduate School Of Science Osaka City University:present Addre
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BERNHEIM FREDERICK
Department of Physiology and Pharmacology, Duke University Medical Center
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NAKAMURA KEIJI
Department of Physiology and Pharmacology, Duke University Medical Center
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